职位详情
职责
- Working closely with Medicinal Chemistry/Biologics Discovery/in vitro Pharmacology teams developing in vivo models to test the activity of test articles and perform in-depth characterization of mechanism studies in these models;
- Collaborate with the broader scientific teams to design and execution vivoPoC experiments aiming at defining the mechanism(s) of action of test articles;
- Perform in-depth literature search, design/execute immunology in vivo models exploring the PD of test articles supporting differentiation points identification/ indication expansion;
- Serve as representative of immunology in vivo team in the project team responsible for addressing technique issues/giving suggestions to support achieving key milestones;
- Responsible for experiment tissue collection/biomarker assessment/data analysis/experiment report drafting/IND submission material drafting;
- Support new target evaluation, MoA analysis and proposal preparation.
入职条件
- Master or PhD degree in the field of immunology, immuno-oncology, pharmacology or veterinary medicine with at least three years (for PhD level candidates) or six years (for Master level candidates) of working experience in industry settings (TopCROs/Pharma/Bio-Pharma/Biotech).
- Strong publication/patent track records are preferred.
- Experience in independently leading immunology & inflammation in vivo projects to PCC/IND milestones are highly preferred.
- Hands-on experience and in-depth knowledge in vivo animal models of inflammatory/autoimmune diseases or Immuno-oncology, proficient in routine animal experiment/handlings kills.
- Hands-on experience and in-depth knowledge in exvivoimmunology/molecular assays/techniques including flow cytometry, ELISA,MSD, Luminex, CBA, western blot, IHC/IF, qPCRetc.
- Experience in sequencing(DNA/RNA)or proteomics data analysis or mathematic/computational modeling is a plus.
- Strong ability in literature/patent search, analytical thinking and problem solving.
- Good verbal/reading/writing skills in English as proved by CET6/IELTS/TOEFL/GRE scores.
- Excellent analytical, organizational and communications skills with demonstrated ability to work collaboratively with peers across multiple functions.
关于公司
概述
先声药业(2096.HK) 成立于 1995 年，是一家创新与研发驱动的制药公司,建设有“神经与肿瘤药物研发全国重点实验室”。公司聚焦神经科学、抗肿瘤、自身免疫及抗感染领域，同时积极前性布局未来有重大临床需求的疾病领域，致力于让患者早日用上更有效药物。公司以自主研发及协同创新双轮驱动，与多家创新企业、科研院校建立战略合作伙伴关系。